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World Congress on Drug Discovery and Drug Design, will be organized around the theme “Current Evolution in Drug Discovery and Drug Design”

Drug Discovery Congress 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Drug Discovery Congress 2019

Submit your abstract to any of the mentioned tracks.

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\r\n Drug design is an inventive process of medication discovered by biological target. It is also known as rational drug design or rational design. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense. Drug design relies on the knowledge of the three-dimensional structure of bimolecular targets. The drug is an organic molecule, when it is predicament to target site it can either inhibit or activate the function of a biomolecule which effects in therapeutic benefit.

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  • Track 1-1Research & development in drug designing
  • Track 1-2Drug targets
  • Track 1-3Drug designing docking
  • Track 1-4Types of drug design
  • Track 1-5Structural based drug designing
  • Track 1-6Pharmacoepidemiology

\r\n The term drug targets regularly used in medicinal research to describe the native protein in the body whose activity is modified by a drug resulting in a distinct effect, which may be a desirable therapeutic effect or an unwanted side effect. In this context, the biological target is often referred to as a biological target. The most common drug targets are G-protein couple receptor, enzymes, ligand gated channels, voltage gated channels, ion channels, nuclear hormone receptor and membrane transport proteins.

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  • Track 2-1Drug targeting
  • Track 2-2Drug toxicity
  • Track 2-3Drug designing
  • Track 2-4Drug design strategies for targeting g-protein-coupled receptors
  • Track 2-5Biological targets
  • Track 2-6Rational drug design

\r\n Computer aided drug design and Advanced Instrumentation is that the most basic goal is to predict whether a given bioactive molecule can bind to a target or not. Study in drug design or biomarkers in drug design measures the conformation of the little molecule and to model conformational changes within the biological target which will occur once the little molecule binds thereto. Recent advances in CADD with the utilization of high performance computing technology and Insilco molecular design computer code and tools offer might optimize the parameters for the molecular mechanics calculations and additionally provide an estimation of the electronic properties (electrostatic potential, polarizability, etc.) of the drug molecule that may influence binding affinity within the use of ultrasound in medicinal chemistry. High-resolution 1H-NMR chemical analysis and X-Ray absorption chemical analysis ways may additionally be accustomed offer semi-quantitative prediction of the required affinity

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  • Track 3-1Bioinformatics in CADD
  • Track 3-2Ligand based CADD
  • Track 3-3Homology modeling
  • Track 3-4Steps Involved in CADD
  • Track 3-5Drug Design Software

Nanotechnology has now introduced to develop medicine. Nanotechnology contains the use of materials with essential length scales in the nanometer measurement which demonstrate significantly changed properties associated to micron structured materials. Such materials can include particles, fibers, grain sizes, etc. This session highlighted the progressions nanotechnology is making in medicine in such fields as disease prevention, diagnosis, and treatment including (but not limited to) drug delivery, tissue engineering, implants, sensors, cancer treatment, an but not limited to) drug delivery, tissue engineering, transplants, sensors, cancer treatment, and toxic

 

  • Track 4-1Current research in nanotechnology
  • Track 4-2Nanotechnology methods in drug design
  • Track 4-3Optimization techniques in drug discovery
  • Track 4-4Future aspects of drug discovery and nanotechnology

\r\n Categorizing drug targets plays crucial roles in designing new drugs and opposing diseases. Unfortunately, our current understanding about drug targets is far from complete. Screening drug targets in the lab is an expensive and time-consuming procedure. In the past decade, the accumulation of various types of study of science related data makes it possible to develop computational approaches to predict drug targets. Non-communicable diseases such as cancer, atherosclerosis and diabetes are responsible for most important social and health disorder as millions of people are dying every year. Out of which, atherosclerosis is the leading cause of deaths globally. The lipid irregularity is one of the most important adjustable risk factors for atherosclerosis. Both genetic and conservation components are associated with the development of atherosclerotic signs

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  • Track 5-1Drug carrier
  • Track 5-2Thinfilm drug delivery
  • Track 5-3Other controlled drug delivery systems
  • Track 5-4Liposomal & target delivery system
  • Track 5-5Identification &validation of drug targets

\r\n Pharmacovigilance is that branch of pharmacology that focuses on analysis, detection and prevention of adverse effects caused by pharmaceutics. Adverse drug reactions (ADRs) are a major cause of patient related morbidity and mortality. Reporting of ADRs is considered to be an important step in maintaining and achieving a safe drug therapy use. Nowadays, Pharmacovigilance hugely emphasizes on challenges like Mass treatment regimens, Un-labelled and Off-labelled indications, Nutritional aspects, New drugs, Adherence, Co-morbidities and Drug resistances. Medication errors such as misuse, overdose, abuse of a drug and drug exposure are some of the reasons responsible for ADRs. The main objective is to generate independent, evidence-based recommendations on the safety of medicines and to monitor benefit-risk profile of different pharmaceutics.

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  • Track 6-1Adverse Drug Reactions
  • Track 6-2Adverse Events
  • Track 6-3Pharmacogenetics and Pharmacogenomics
  • Track 6-4Pharmacoepidemiology

\r\n Proteomics, the large-scale analysis of proteins, contributes expressively to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale certification of proteins and their post-translational changes; (2) 'differential display' proteomics for comparison of protein levels with potential application in a extensive range of diseases; and (3) studies of protein–protein interactions using methods such as mass spectrometry or the yeast two-hybrid system. Proteomics technologies are under nonstop progresses and new skills are introduced. Nowadays high quantity acquisition of proteome data is possible.
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  • Track 7-1Emerging trends in proteomics
  • Track 7-2Bioinformatics for proteomics
  • Track 7-3Current research methodologies in proteomics
  • Track 7-4Structural proteomics
  • Track 7-5Practical applications of proteomics

\r\n The discovery and evaluation of any novel biomarkers will ideally be specialized to Clinical Laboratory Improvement Amendments (CLIA) and Good Clinical Laboratory Practice (GCLP) standards, so as to ensure accuracy and reproducibility of laboratory procedures. Predictive biomarkers indicate the likelihood of response to a specific antitumor therapy. Such assays should be scientifically sound, Predictive biomarkers include both tumor-specific and surrogate biomarkers, and are crucial to accelerating the drug development process

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  • Track 8-1Biomarker Discovery for Immuno-Oncology Agents
  • Track 8-2Biomarkers in Drug Design & Clinical Trial
  • Track 8-3Dose-Selection Biomarkers
  • Track 8-4Biomarkers of Toxicity & Pharmacology
  • Track 8-5Biomarkers of Efficacy

\r\n Drug design is the method of inventing innovative medications. Drug design defines the design of molecules that are corresponding in shape and charge to the bio molecular target with which they interact and therefore will bind to it. Generally, the drug is a tiny organic molecule which triggers or slows down the activity of a bio-molecule such as a protein which repeatedly results in a medicinal benefit to the patient. Discovery of drugs is challenging. Various medications are invented by chance observations, the scientific examination of other medicines or by finding out the side effects of some other drugs. A methodical technique is significant screening observations where important drug targets are tested with thousands of various compounds to observe, whether conversations occur. Basically, drug design involves design of small molecules that are harmonizing in shape and charge to the bio molecular target to which they act together and consequently will bind to it.

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  • Track 9-1Innovative Strategies of Drug Design & Development
  • Track 9-2Synthesis in Drug Discovery
  • Track 9-3Pharmacogenetics in Drug Discovery
  • Track 9-4Stages of Drug Discovery
  • Track 9-5Structure based drug design
  • Track 9-6Drug targets
  • Track 9-7Drug Release Testing
  • Track 9-8Alternative Trials Design & Models

\r\n Clinical Biotherapeutic aspects including study drug design, drug-drug interactions, QT assessment, immunogenicity, comparability, special populations (hepatic and liver failure), PK and PD, regulatory expectations of PK and PD characterization, as well as reviewing factors which influence the ADME of Biotherapeutics. The objectives of early clinical development of therapeutic proteins are the same as for small molecules i.e. to investigate the molecule in a manner that will gain necessary knowledge about its tolerability safety pharmacokinetics (PK) and if possible pharmacodynamics (PD) effects in the most appropriate human populations while simultaneously protecting their safety. However, there are specific features of proteins that must be considered when designing clinical pharmacology studies.

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  • Track 10-1Discovery & Preclinical Testing
  • Track 10-2Clinical Study Designs
  • Track 10-3Data Collection & Quality Control
  • Track 10-4Advanced Information Technology in Clinical trials
  • Track 10-5Clinical Trial Protocol
  • Track 10-6Recent Technology in Biopharmaceuticals

\r\n In revelation process incorporates the early periods of research, which are intended to recognize a drug and perform essential tests in the lab. This initially phase of the procedure takes around three to six years. Before the end, scientists plan to distinguish a promising medication competitor to additionally think about in the lab and in creature models, and afterward in individuals. These advances offer extraordinary guarantee, yet additionally add unpredictability to the Research and development process. With a specific end goal to guarantee the wellbeing and viability of customized treatments that are utilized close by diagnostics, clinical trial conventions must be adjusted and upgraded. This may require the utilization of extra systems and assets, and in addition new or creative types of information accumulation. In addition, by their extremely nature, the patient populace distinguished to react to focused treatments is smaller, which makes tolerant enrolment more troublesome.

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  • Track 11-1Successful Drug Discovery from the Research Lab to the Marketplace
  • Track 11-2Recent Developments in Pharmaceutical Field
  • Track 11-3Process Chemistry and Drug Manufacturing

 

The modern drug discovery process is an overview to the development of new drugs. Now a days new biological targets, methodologies and advanced computing have enhanced modern drug discovery and have given medicinal chemistry a more thoughtful skill set and toolkit to hold the nuances  of disease pathophysiology. The medicinal chemistry related methodologies and a methodology in drug discovery improves the efficiency   in drug discovery and lessening attrition. In drug designing, structure-based drug design, and fragment –based drug design, natural product-based drug design, diversity-based drug design, and chemo genomics are applied.

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  • Track 12-1Protein Kinases in Immunology and Oncology
  • Track 12-2Inhibitors Discovery Strategies in Medicinal Chemistry
  • Track 12-3Medicinal Chemistry for Autoimmune Diseases
  • Track 12-4Neuroscience Drug Discovery
  • Track 12-5CNS – Interfacing Chemistry and Biology to Advance

\r\n Nanotechnology, a multidisciplinary logical endeavor, includes creation and use of materials, gadgets or frameworks on the nanometer scale. The field of nanotechnology is as of now experiencing hazardous improvement on many fronts. The innovation is required to make developments and assume a basic part in different biomedical applications, in drug delivery, as well as in atomic imaging, biomarkers and biosensors. Target-specific drug therapy and strategies for early finding of pathologies are the need look into territories where nanotechnology would assume a crucial part. Diverse nanotechnology-based drug delivery and imaging approaches and their monetary effect assume fundamental part in pharmaceutical and biomedical enterprises.

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  • Track 13-1Screening and design
  • Track 13-2Nanotechnology methods in Drug Design
  • Track 13-3Nanotechnology Fundamental Concepts
  • Track 13-4Current Research in Nanotechnology
  • Track 13-5Nanomedicine
  • Track 13-6Nanometrology

\r\n Drug metabolism is the procedure by which the body separates and changes over prescription into dynamic concoction substances. It is the enzymatic transformation of one concoction compound into another. Drugs can be utilized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization; whatever the procedure, the objective is to make the drug less demanding to discharge. The proteins engaged with metabolism are available in many tissues however for the most part are more moved in the liver. Drug metabolism rates shift among patients. A few patients use a drug so quickly that therapeutically compelling blood and tissue focuses are not come to; in others, metabolism might be slow to the point that standard dosages have dangerous impacts. Singular drug metabolism rates are affected by hereditary factors, existing together disorders (especially unending liver disorders and propelled heart disappointment), and drug connections (particularly those including acceptance or restraint of metabolism). By and large, metabolic procedures will change over the drug into a more water-dissolvable compound by expanding its extremity.

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  • Track 14-1Phase I – modification
  • Track 14-2Phase II – conjugation
  • Track 14-3Phase III – further modification and excretion

\r\n Chemoinformatic plays a vital link between made-up design and in drug design through mining of information from the data and translate into knowledge. Derivation of information and knowledge is only one aspect of chemoinformatic. The use of consequent knowledge in a design and selection support role is an important part of the drug design cycle. The main processes within drug discovery are lead documentation, where a lead is something that has activity in the low micro molar range, and lead optimization, which is the process of transforming a lead into a drug candidate. Chemo informatics methods can be used proactively to designing and filter the most appropriate compounds to work within the real world.

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  • Track 15-1Information aquisation and process of generating and collecting data
  • Track 15-2Prediction of physical,chemical and biological properties of chemical compounds
  • Track 15-3Elucidation of the structure of a compounds based on data
  • Track 15-4Structure, similarity and diversity searching from chemical database
  • Track 15-5Docking- interaction between two macromolecules

\r\n The process by which a drug is distributed can have an important effect on its efficacy Some drugs have an optimum concentration range within which extreme benefit is derived, and concentrations above or below this range can be noxious or produce no therapeutic benefit at all. On the other hand, the very slow improvement in the efficacy of the treatment of severe diseases, has optional a growing need for a multidisciplinary approach to the delivery of therapeutics to targets in tissues. These nanoparticles would be loaded with drugs and plagued to specific parts of the body where there is completely diseased tissue, thereby avoiding interaction with healthy tissue. The goal of a targeted drug delivery system is to extend, localize, target and have a vulnerable drug interaction with the diseased muscle

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  • Track 16-1Targeted drug delivery
  • Track 16-2Proteins and surfaces
  • Track 16-3Pulmonary drug delivery
  • Track 16-4Blood brain barrier delivery
  • Track 16-5Antibody targeted drug conjugates
  • Track 16-6Genedelivery